After landing at the airport in Albuquerque, pick up your car and drive along the incredibly scenic Turquoise Trail, a byway linking Albuquerque and Santa Fe that takes about 90 minutes. Along this route, be sure to stop at some of the alluring pottery shops and galleries in the town of Madrid and the sculpture garden in Cerrillos. Continue on to Santa Fe and check into the Rosewood Inn of the Anasazi hotel downtown.

I recommend heading to the rooftop cantina at Coyote Cafe for prime sunset viewing while sipping a creative cocktail. For dinner, head downstairs to the restaurant for contemporary Southwestern cuisine that highlights native ingredients.

Spend today exploring downtown Santa Fe. Breakfast at lively Cafe Pasqual’s is delicious, and the restaurant offers a sense of the true spirit of Santa Fe. First-time visitors to the city shouldn’t miss the Georgia O’Keeffe Museum, the Loretto Chapel (to see the “miraculous staircase”) and the San Miguel Chapel, a beautiful Spanish Colonial mission. Along the arcade in front of the adobe Palace of the Governors, you can meet artisans from various pueblos throughout New Mexico and buy their handmade crafts and jewelry. The Compound and Restaurant Martín are excellent options for lunch and dinner.

Book a morning class at the Santa Fe School of Cooking, which is popular with both tourists and locals alike. The school offers lessons designed to educate students on the culinary traditions of northern New Mexican cuisine. You can choose a session that concentrates on a specific dish, such as tamales or rellenos, or a session that highlights a particular ingredient, such as green or red chiles. We signed up for the outstanding Traditional New Mexican class, which provided a much broader picture of Southwestern cooking techniques. Lunch is included, and beverages can be purchased.

Head out early this morning and drive to the Puye Cliff Dwellings in the Santa Clara Canyon, 45 minutes from downtown Santa Fe. This was the home of more than 1,500 Santa Clara Pueblo Indians between the 10th century and about 1580, when a fire drove them to the lower Rio Grande River Valley. These original dwellings were caves hollowed into the cliff face, and the mesa top was the location of the kiva (subterranean ceremonial chamber) and community structures. The tour is fascinating, as visitors can explore these caves and climb down into the kiva. (However, we do not recommend this tour for those scared of heights or with mobility issues.)

If you are interested in visiting a traditional weaving shop, make your way to the one-of-a-kind Centinela Traditional Arts in the small town of Chimayó. The owner, Irvin, is happy to show visitors his loom, and the tapestries hung high on adobe-style walls are beautiful.

From here, head to the legendary town of Taos, which is a 70-minute drive away. We have not found a hotel in Taos that is up to Andrew Harper standards, but the Taos Inn is a historic property conveniently located downtown. If you stay the night in Taos, the best restaurant for dinner is the Love Apple. My spring pea salad with a creamy poblano buttermilk dressing was outstanding, as was the baked tamal in a traditional mole sauce.

Enjoy a traditional Southwestern breakfast at the Taos Inn, then spend the morning exploring the town. Taos has a storied past as an art colony, and visiting museums dedicated to some of the most famous of the luminaries who made the town their home is riveting. The Millicent Rogers Museum and the residence of painter E.L. Blumenschein were my two favorites. The Taos Pueblo is a great stop to pick up handmade crafts by local Indian inhabitants.

From here, head up to Vermejo Park Ranch, nearly three hours to the northeast, an exceptional hotel owned by media mogul Ted Turner. The ranch encompasses nearly 585,000 acres, a large herd of resident bison, a main lodge surrounded by guesthouses and an eight-bedroom lodge located at an elevation of 10,200 feet (book a room in the opulent Casa Grande). A range of activities includes seasonal turkey hunts, fishing trips, wildlife safari tours, horseback riding and photography workshops. This ranch feels like a national park that is free of all visitors, and we recommend at least three days here.

It will be hard to leave Vermejo Park Ranch, but Ojo Santa Fe, a beautiful wellness retreat outside Santa Fe, provides some compensation. The main draw of the hotel is the extensive list of fitness and wellness classes, which range from arts workshops to gardening classes to unique interactions with chickens as well as puppies in training to be service dogs. The spa is, as expected for a destination health retreat, first-rate, but be sure not to miss the mineral-infused open-air soaking tubs and Japanese-style wooden tubs.

The cuisine in the on-site restaurant is excellent, but for a fine-dining experience nearby, head to Arroyo Vino, which offers an Italian-influenced contemporary menu that changes seasonally. It also has a well-stocked wine shop.

After two days at the serene oasis of Ojo Santa Fe, you will leave feeling rejuvenated and healthier. Though the spa resort feels a world away from bustling downtown Santa Fe, it takes only 20 minutes to get to your next hotel, The Inn of the Five Graces, just a short walk from the historic Sena Plaza. After check-in, explore the winding gallery-lined Canyon Road.

I recommend having dinner at El Farol, a gourmet Spanish restaurant conveniently located in the heart of this area. Reserve one of the dinner shows in advance to watch dancers from the National Institute of Flamenco perform.